Diethyl(phenylacetyl)malonate
- CasNo：20320-59-6
- Molecular Formula：C15H18O5
- Purity：
- Molecular Weight：278.305
Product Details
Chinese Factory Supply High Purity Diethyl(phenylacetyl)malonate 20320-59-6 Intermediates In Stock, GMP Manufacturer
- Molecular Formula:C15H18O5
- Molecular Weight:278.305
- Boiling Point:120 °C(Press: 0.01 Torr)
- PKA:8.76±0.59(Predicted)
- PSA：69.67000
- Density:1.148±0.06 g/cm3(Predicted)
- LogP:1.54060
Diethyl(phenylacetyl)malonate(Cas 20320-59-6) Usage
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Physical properties |
Diethyl(phenylacetyl)malonate has a boiling point of 120 °C. Its density is predicted to be 1.148±0.06 g/cm3. |
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Uses |
Organic synthesis intermediates. Malonate is a three-carbon dicarboxylic acid. It is also involved in the synthesis of pharmaceuticals like chloroquine, butazolidin and barbital. |
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Preparation |
The anhydrous ethanol co-vaporized with diethyl phthalate and sodium metal is added dropwise to the mixture of diethyl malonate, carbon tetrachloride and magnesium, heated to start the reaction, and the temperature is controlled to smooth the reaction. Then add anhydrous diethyl ether, heat for 1h, add the diethyl ether solution of phenylacetyl chloride (add slowly, not to make the reaction too intense). After the reaction is completed, cool and add water, separate the oil layer, and evaporate the diethyl ether under reduced pressure to obtain diethyl(phenylacetyl)malonate. |
Isomeric SMILES: CCOC(=O)C(C(=O)CC1=CC=CC=C1)C(=O)OCC
InChIKey: ZASPDQDIPTZTQQ-UHFFFAOYSA-N
InChI: InChI=1S/C15H18O5/c1-3-19-14(17)13(15(18)20-4-2)12(16)10-11-8-6-5-7-9-11/h5-9,13H,3-4,10H2,1-2H3
20320-59-6 Relevant articles
693. cyclo Hexane-1: 3-diones. Part II. A new synthesis of substituted p-terphenyls
GR Ames, W Davey
, Journal of the Chemical Society (Resumed), 1957
… by Michael addition of diethyl malonate to benzyl styryl … -catalysed addition of diethyl malonate to benzyl styryl ketone (I)… from phenylacetyl chloride and diethyl ethoxymagnesiomalonate…
The Interrupted Pummerer Reaction in a Sulfoxide-Catalyzed Oxidative Coupling of 2-Naphthols
He, Zhen,Pulis, Alexander P.,Procter, David J.
supporting information, p. 7813 - 7817 (2019/05/15)
A benzothiophene S-oxide catalyst, gener...
Kinetics and mechanism of the stepwise dissociation of iron (III) from ferrioxamine B in aqueous acid
B Monzyk, AL Crumbliss
J. Am. Chem. Soc. 1982, 104, 18, 4921–4929
Then the anion of dimethyl malonate (6 mmol) in 12 mL of THF was added at 25 C under CO to give a light red solution immediately. The red color faded into light amber (~5 min). After …
20320-59-6 Process route
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- 103-80-0
phenylacetyl chloride
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- 105-53-3
diethyl malonate
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- 20320-59-6
diethyl 2-(2-phenylacetyl)malonate
| Conditions | Yield |
|---|---|
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diethyl malonate; With ethanol; magnesium; In tetrachloromethane; toluene; for 1h; Heating;
phenylacetyl chloride; In tetrachloromethane; toluene; at 20 ℃; for 1h;
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90% |
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With chloroform; magnesium;
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With magnesium;
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With sodium;
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Multistep reaction; (i) Mg, EtOH, (ii) /BRN= 742254/;
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diethyl malonate; With triethylamine; magnesium chloride; In acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;
phenylacetyl chloride; In acetonitrile; at 20 ℃;
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With magnesium; In ethanol; toluene; at 80 ℃;
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diethyl malonate; With sodium hydride; In tetrahydrofuran; for 1h;
phenylacetyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
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489 mg |
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- 64-17-5
ethanol
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- 74965-87-0
2,2-dimethyl-5-(2-phenylacetyl)-1,3-dioxane-4,6-dione
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- 20320-59-6
diethyl 2-(2-phenylacetyl)malonate
| Conditions | Yield |
|---|---|
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for 3h; Reflux;
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20320-59-6 Upstream products
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996-82-7
sodium diethylmalonate
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103-80-0
phenylacetyl chloride
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105-53-3
diethyl malonate
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570-08-1
diethyl acetylmalonate
20320-59-6 Downstream products
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621-06-7
2,N-diphenylacetamide
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20280-94-8
4-benzyl-7-hydroxycoumarin
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20597-30-2
2-Benzylmercapto-3-phenyl-1-propen-1,1-dicarbonsaeure
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101981-93-5
Naphthalin-2-sulfonsaeure-<1-benzyl-2,2-diaethoxycarbonyl-vinyl-ester>
