Guanidine thiocyanate

  • CasNo:593-84-0
  • Molecular Formula:C<sub>2</sub>H<sub>6</sub>N<sub>4</sub>S
  • Purity:
  • Molecular Weight:118.162
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What is the Guanidine thiocyanate ?

Guanidine thiocyanate is White cryst. powder, while it's Molecular Formula is C2H6N4S. Guanidine thiocyanate has been used as a component of the stabilization buffer for RNA lysis. It can be used for deactivation of endogenous RNases leading to denaturation of nucleoprotein complexes. It is also suitable for denaturation of macromolecules such as nucleic acids and proteins and for RNA isolation.

What is the CAS number for Guanidine thiocyanate ?

The CAS number of Guanidine thiocyanate is 593-84-0.

More information of Guanidine thiocyanate 593-84-0 are:

Synonyms

Isothiocyanic acid, compd. with guanidine (1:1);

CAS Number

593-84-0

Molecular Formula

C2H6N4S

Molecular Weight

118.162

Density

1.103 g/mL at 20 °C

Melting Point

120-122 °C(lit.)

Boiling Point

132.9 °C at 760 mmHg

Flash Point

34.2 °C

HS CODE

29252000

PSA

138.48000

LogP

0.73618

Pka

12.5[at 20 ℃]

What is Guanidine thiocyanate (593-84-0) used for?

Guanidine thiocyanate is one of the cheapest and easiest to prepare of the guanidine salts. Guanidine Thiocyanate is an ultrapure, molecular biology grade reagent. It is free of detectable nuclease and protease activity and is a strong protein denaturant, as both the guanidinium cation and the thiocyanate anion are chaotropic agents. It is provided in one bottle containing 500 g. It is recommended for isolation of RNA, especially for tissues such as pancreas with high levels of RNase activity. In solution, it is known as guanidinium thiocyanate. Guanidine Thiocyanate is thoroughly tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.

InChI:InChI=1/C2H4N4S/c3-1-7-6-2(4)5/h(H4,4,5,6)

Articles related to Guanidine thiocyanate:

Article

Source

Kinetics of thermal decomposition of thiourea

Timchenko,Novozhilov,Slepysheva

, p. 1046 - 1050 (2007/10/03)

RNA extraction by the guanidine thiocyanate procedure R McGookin - Nucleic Acids, 1984
Molecular hybridization with RNA probes in concentrated solutions of guanidine thiocyanate J Thompson, D Gillespie - Analytical biochemistry, 1987
Thermally-induced desulfurization and conversion of guanidine thiocyanate into graphitic carbon nitride catalysts for hydrogen photosynthesis B Long, J Lin, X Wang - Journal of Materials Chemistry A, 2014

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