Guanidine thiocyanate

  • CasNo:593-84-0
  • Molecular Formula:C<sub>2</sub>H<sub>6</sub>N<sub>4</sub>S
  • Purity:
  • Molecular Weight:118.162

Product Details

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What is the Guanidine thiocyanate ?

Guanidine thiocyanate is White cryst. powder, while it's Molecular Formula is C2H6N4S. Guanidine thiocyanate has been used as a component of the stabilization buffer for RNA lysis. It can be used for deactivation of endogenous RNases leading to denaturation of nucleoprotein complexes. It is also suitable for denaturation of macromolecules such as nucleic acids and proteins and for RNA isolation.

What is the CAS number for Guanidine thiocyanate ?

The CAS number of Guanidine thiocyanate is 593-84-0.

More information of Guanidine thiocyanate 593-84-0 are:


Isothiocyanic acid, compd. with guanidine (1:1);

CAS Number


Molecular Formula


Molecular Weight



1.103 g/mL at 20 °C

Melting Point

120-122 °C(lit.)

Boiling Point

132.9 °C at 760 mmHg

Flash Point

34.2 °C








12.5[at 20 ℃]

What is Guanidine thiocyanate (593-84-0) used for?

Guanidine thiocyanate is one of the cheapest and easiest to prepare of the guanidine salts. Guanidine Thiocyanate is an ultrapure, molecular biology grade reagent. It is free of detectable nuclease and protease activity and is a strong protein denaturant, as both the guanidinium cation and the thiocyanate anion are chaotropic agents. It is provided in one bottle containing 500 g. It is recommended for isolation of RNA, especially for tissues such as pancreas with high levels of RNase activity. In solution, it is known as guanidinium thiocyanate. Guanidine Thiocyanate is thoroughly tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.


Articles related to Guanidine thiocyanate:



Kinetics of thermal decomposition of thiourea


, p. 1046 - 1050 (2007/10/03)

RNA extraction by the guanidine thiocyanate procedure R McGookin - Nucleic Acids, 1984
Molecular hybridization with RNA probes in concentrated solutions of guanidine thiocyanate J Thompson, D Gillespie - Analytical biochemistry, 1987
Thermally-induced desulfurization and conversion of guanidine thiocyanate into graphitic carbon nitride catalysts for hydrogen photosynthesis B Long, J Lin, X Wang - Journal of Materials Chemistry A, 2014

How to get the cheap price on Guanidine thiocyanate?

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