• CasNo:157115-85-0
  • Molecular Formula:C<sub>17</sub>H<sub>22</sub>N<sub>2</sub>O<sub>4</sub>
  • Purity:
  • Molecular Weight:318.373

Product Details

High Quality Pharmaceutical Grade Noopept 157115-85-0

  • Molecular Formula:C17H22N2O4
  • Molecular Weight:318.373
  • Appearance/Colour:white powder 
  • Vapor Pressure:4.93E-12mmHg at 25°C 
  • Melting Point:94.0 to 98.0 °C 
  • Refractive Index:1.548 
  • Boiling Point:547.3°Cat760mmHg 
  • PKA:13.41±0.20(Predicted) 
  • Flash Point:284.8°C 
  • PSA:75.71000 
  • Density:1.202g/cm3 
  • LogP:1.22820 

ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate(Cas 157115-85-0) Usage


Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester , a synthetic nootropic molecule. It has a similar effect to piracetam, in that it provides a mild cognitive boost after supplementation. It also provides a subtle psychostimulatory effect. Noopept is up to 1000-times more potent than the original racetam, Piracetam.

Chemical Properties

Noopept is a synthetic nootropic molecule grouped in the racetam class but structurally different from racetams.It is primarily water-soluble nootropic, but won't easily dissolve in water or juice. So it may help if you take it with a meal containing healthy fats.


Noopept (previously GVS-111) is a nootropic developed at the Zakusov Institute of Pharmacology (Russian Academy of Medical Sciences) by T. A. Gudasheva. It is one of several nootropics developed based on the structure of piracetam. Its advantage over piracetam is that it can be taken at a lower dose.Noopept is a popular cognitive-enhancing supplement in the nootropic community. Proposed mechanism of actions based on preclinical studies include increasing acetylcholine signaling, increasing the expression of BDNF and NGF, protecting from glutamate toxicity, and increasing inhibitory neurotransmission in the


Noopept is a well-known nootropic that is often suggested as a first nootropic.Noopept is over 500 times more potentthan Piracetam.Like piracetam,it is capable of enhancing memory,learning,andfocus. Noopept is also a powerful antioxidant that prevents neurological disorders andhelps the brain grow.Because of this, it is thought to improve long-term memory. The human studies have shown promising results, with potential application in the treatment of Alzheimer's disease.

Biochem/physiol Actions

Noopept is a nootropic and neuroprotective drug that normalizes the balance of the pro- and antioxidant systems. Noopept modulates a variety of physiological functions including cognition and anxiety. Noopept significantly weakens streptozotocin-Induced diabetes in rats.

Side effects

Noopept is associated with some mild side effects based on limited clinical evidence. possible side effects of noopept included sleep disturbances (5/31 patients), irritability (3/31), and increased blood pressure (7/31) (Neznamov and Teleshova, 2009).


Noopept (ethyl ester of N-phenylacetyl-L-prolylglycine) was designed as a drug at State Zakusov Institute of Pharmacology. The synthesis of the drug is based on the original hypothesis of peptide design, according to which structures similar to known psychotropic agents are reproduced using appropriate amino acids. The non-peptide prototype of Noopept is the nootropic drug Piracetam.1. Perform the carboxylation of N-phenylacetyl-L-proline and ethyl glycine in the presence of isobutyl chloroformate. 2. Add slowly isobutyl chloroformate (1.17 g, 8.6 mmol) to a solution of N-phenylacetyl-L-proline (2.0 g, 8.6 mmol) dissolved in a mixed solvent of THF and dichloromethane (1:1; THF/dichloromethane (v/v)).3.Stir the mixture for 4 h at 0 ~5 °CMolecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept


157115-85-0 Relevant articles

Synthesis and antiamnesic activity of a series of N-acylprolyl-containing dipeptides


, p. 151 - 157 (2007/10/03)

Eaters and amides of a series of N-acylp...

157115-85-0 Process route

glycine ethyl ester hydrochloride

glycine ethyl ester hydrochloride



N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions Yield
With 4-methyl-morpholine; In chloroform; N,N-dimethyl-formamide; at -5 - 20 ℃; for 1.5h; Yield given;
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions Yield
Multi-step reaction with 2 steps
1: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C
2: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C
With 4-methyl-morpholine; In chloroform; N,N-dimethyl-formamide;

157115-85-0 Upstream products

  • 623-33-6

    glycine ethyl ester hydrochloride

  • 2752-38-7

    (S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

  • 103-80-0

    phenylacetyl chloride

  • 147-85-3


157115-85-0 Downstream products

  • 157115-95-2