2-Oxo-4-phenyl-1-pyrrolidineacetic acid hydrazide 77472-71-0
- CasNo：77472-71-0
- Molecular Formula：
- Purity：
- Molecular Weight：
Product Details
77472-71-0 Properties
- Molecular Formula:C12H15N3O2
- Molecular Weight:233.27
- Melting Point:154-155 °C
- Boiling Point:529.4±50.0 °C(Predicted)
- PSA：75.43000
- Density:1.243±0.06 g/cm3(Predicted)
- LogP:1.02150
77472-71-0 Usage
Uses
2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide is mainly used as pharmaceutical intermediates.
Uses
2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide is mainly used as pharmaceutical intermediates.
77472-71-0 Relevant articles
2-[4-(Het)aryl-2-oxopyrrolidin-1-yl]acetohydrazides: synthesis, structures, and reactions with carbonyl compounds
Baichurin, R. I.,Gorodnicheva, N. V.,Karamov, F. A.,Litvinov, I. A.,Lodochnikova, O. A.,Makarenko, S. V.,Ostroglyadov, E. S.,Vasil’eva, O. S.
, p. 996 - 1008 (2020)
2-[4-(Het)aryl-2-oxopyrrolidin-1-yl]acetohydrazides, structural analogs of piracetam, were synthesized by the condensation of 2-[4-(het)aryl-2-oxopyrrolidin-1-yl]acetates with hydrazine hydrate and phenylhydrazine. New [N′-alkyl(hetaryl)idene]-4-(het)aryl-2-oxopyrrolidin-1-ylacetohydrazides were synthesized by the reaction of 2-[4-(het)aryl-2-oxopyrrolidin-1-yl]-acetohydrazides with aromatic aldehydes, acetone, and acetophenone.
THE SYNTHESIS AND ANTISPASMODIC ACTIVITY OF 4-PHENYLPYRROLIDONE-2-ACETAMIDES
Glozman, O. M.,Morozov, I. S.,Zhmurenko, L. A.,Zagorevskii, V. A.
, p. 776 - 780 (2007/10/02)
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77472-71-0 Process route
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70291-40-6
2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester
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77472-71-0
2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide
| Conditions | Yield |
|---|---|
|
With
hydrazine hydrate;
at 0 - 20 ℃;
for 20h;
|
78% |
|
With
hydrazine hydrate;
In
ethanol;
for 8h;
Heating;
|
67% |
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1198-97-6
4-phenylpyrrolidin-2-one
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77472-71-0
2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h
2: 67 percent / hydrazine hydrate / ethanol / 8 h / Heating
With
sodium hydride; hydrazine hydrate;
In
ethanol;
|
77472-71-0 Upstream products
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70291-40-6
2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester
-
1198-97-6
4-phenylpyrrolidin-2-one
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77519-55-2
2-oxo-4-phenylpyrrolidine-3-carboxylic acid
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55790-17-5
3-methoxycarbonyl-4-phenyl-2-pyrrolidone
