Sildenafil Citrate 171599-83-0
- CasNo：171599-83-0
- Molecular Formula：C6H8O7*C22H30N6O4S
- Purity：
- Molecular Weight：
Product Details
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171599-83-0 Name |
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Name |
Sildenafil citrate |
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Synonym |
Viagra, Sildenafil citrate;1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt;5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt;1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 2-hydroxy-1,2,3-propanetricarboxylate;Sildenafil Citrate (100 mg);Sildenafil citrate, >=99%;Sildenafil citrate, Professional supply;5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one citrate |
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171599-83-0 Chemical & Physical Properties |
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Melting point |
187-189ºC |
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Boiling point |
672.4ºC at 760 mmHg |
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Density |
1.447g/cm3 |
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Molecular Formula |
C28H38N6O11S |
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Molecular Weight |
666.700 |
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Flash Point |
360.5ºC |
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PSA |
253.93000 |
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LogP |
1.31900 |
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Exact Mass |
666.231934 |
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Vapour Pressure |
0mmHg at 25°C |
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Storage condition |
Desiccate at RT |
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Stability |
Store in Freezer |
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Index of Refraction |
1.683 |
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171599-83-0 Description |
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Sildenafil Citrate is the citrate salt form of sildenafil, an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection. In the smooth muscle of the pulmonary vasculature, the increase in cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed, relieving pulmonary hypertension and increasing blood flow in the lungs. In addition, sildenafil may reduce airway inflammation and mucus production. |
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171599-83-0 Uses |
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Sildenafil citrate is an orally active selective type 5 cgmp phosphodiesterase inhibitor that is used in the treatment of erectile dysfunction and primary pulmonary hypertension. |
