β-Nicotinamide mononucleotide
- CasNo：1094-61-7
- Molecular Formula：C11H15 N2 O8 P
- Purity：
- Molecular Weight：
Product Details
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1094-61-7 Name |
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Name |
β-Nicotinamide Mononucleotide |
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Synonym |
NMN;BETA-NMN;BETA-NICOTINAMIDE MONONUCLEOTIDE;BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;B-NICOTINAMIDE MONONUCLEOTIDE;NMN;NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE;NICOTINAMIDE RIBOTIDE |
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1094-61-7 Biological Activity |
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Description |
β-nicotinamide mononucleotide is an intermediate in NAD+ biosynthesis produced from nicotinamide (NAM) and phosphoribosyl pyrophosphate (PRPP) by nicotinamide phosphoribosyl transferase enzyme. |
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Related Catalog |
Natural Products >> Saccharides and Glycosides Research Areas >> Others |
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Target |
Human Endogenous Metabolite |
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1094-61-7 Chemical & Physical Properties |
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Melting point |
166 °C(dec.) |
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solubility |
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
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Molecular Formula |
C11H15N2O8P |
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Molecular Weight |
334.219 |
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LogP |
-3.38 |
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PSA |
176.06000 |
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Exact Mass |
334.056610 |
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Storage condition |
2-8°C |
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1094-61-7 Description |
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Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+. |
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1094-61-7 Application |
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β-Nicotinamide mononucleotide (NMN) is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice . It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. It is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. |
