4-Amino-3-phenylbutyric acid hydrochloride

  • CasNo:1078-21-3
  • Molecular Formula:C10H13NO2
  • Purity:
  • Molecular Weight:
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Product Details

1078-21-3 Name

Name

4-Amino-3-phenylbutyric acid hydrochloride

Synonym

Phenibut;4-AMINO-3-PHENYLBUTANOIC ACID HYDROCHLORIDE;4-AMINO-3-PHENYLBUTIRIC ACID;-Amino-3-phenylbutyric acid hydrochloride;NA###4-Amino-3-phenylbutyric acid hydrochloride;PHENIBUTCAS NO.: 1078-21-3 Phenibut CAS NO.1078-21-3;Nootropics Powder Nutrition Supplement Phenibut for Fatigue Reduce CAS 1078-21-3;TIMTEC-BB SBB001567;PHENIBUT

 

1078-21-3 Chemical & Physical Properties

Melting point 

194.0-202.0°C

Boiling point

311.75°C (rough estimate)

Density

1.1248 (rough estimate)

Molecular Formula

C10H14ClNO2

Molecular Weight

215.677

PSA

63.32000

LogP

2.70590

Exact Mass

215.071304

Index of Refraction

1.5710 (estimate)

solubility

Free base: 35 mg/mL in DMSO (195.29 mM) at 25 °C (SellekChem, 2019).Hydrochloride salt (Cayman, 2016): 25 mg/ml in DMF; 20 mg/ml in DMSO; 14 mg/ml in ethanol; 10 mg/mL in PBS (pH 7.2).

 

1078-21-3 Description

Phenibut, also known as fenibut, phenigamma, and beta-phenyl-gamma-aminobutyric acid, is a derivative of the neurotransmitter GABA. It was developed in Russia,and there it has been used clinically since the 1960s to treat anxiety and related conditions,including insomnia(Lapin,2001). Phenibut has anxiolytic properties and is commonlycompared to benzodiazepines and baclofen.Structurally,phenibut issimilar to GABA, with the addition of the phenyl ring. This allows thecompound to more easily cross the blood-brain barrier, but also changesits activity profile (Shulgina,1986). Scientific studies demonstrate that phenibut can be safely used to treat anxiety, depression,epilepsy, speech disorders, and insomnia.

 

1078-21-3 Uses

  1. amino-3-phenylbutanoic acid (cas# 1078-21-3) is a GABAA receptor agonist, used for treatment of disorders influenced by dysfunction of pancreatic β cells and also used in combination with other agents.

Phenibut is an anxiolytic and nootropic drug, discovered in the Soviet Union used to treat several psychiatric disorders. It can be used in the treatment of anxiety, depression, asthenia, post-traumatic stress disorder, stuttering, and vestibular disorders.