Choline glycerophosphate
- CasNo：28319-77-9
- Molecular Formula：C8H20NO6P
- Purity：
- Molecular Weight：
Product Details
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28319-77-9 Name |
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Name |
Choline glycerophosphate |
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Synonym |
2-[[(2R)-2,3-dihydroxypropoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium;L-A-GLYCEROPHOSPHORYLCHOLINE FROM*EGG YOLK FREE FORM;L-A-GLYCEROPHOSPHORYLCHOLINE FROM SOYBEAN, FREE FORM;L-α-GLYCERYLPHOSPHORYLCHOLINE(GPC);,hydroxide,innersalt,(r)-;L-a-Glycerophosphorylcholine (anhydrous) (GPC);L-α-Glycerophosphorylcholine;GLYCERYLPHOSPHOCHOLINE |
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28319-77-9 Biological Activity |
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Description |
L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2]. |
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Related Catalog |
Signaling Pathways >> Neuronal Signaling >> AChE Natural Products >> Others Research Areas >> Neurological Disease |
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Target |
Human Endogenous Metabolite |
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References |
[1]. Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9.[2]. Barbagallo Sangiorgi G, et al. Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks." An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69. |
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28319-77-9 Chemical & Physical Properties |
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Melting point |
-98ºC |
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Boiling point |
480℃[at 101 325 Pa] |
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Molecular Formula |
C8H20NO6P |
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Molecular Weight |
257.221 |
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Flash Point |
11 °C |
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PSA |
108.86000 |
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LogP |
-5.63 |
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Exact Mass |
257.102814 |
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Appearance of Characters |
Solid |
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Index of Refraction |
1.329 (20ºC) |
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storage temp. |
-20°C |
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solubility |
DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly) |
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Water Solubility |
1000g/L at 25℃ |
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28319-77-9 Description |
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Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine. |
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28319-77-9 Uses |
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