Product Details
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49557-75-7 Name |
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Name |
Copper Tripeptide-1 |
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Synonym |
GHK Cu Copper Peptide;L-Lysine,glycyl-L-histidyl-;Copper Peptide powder (GHK-cu);GHK Cu Copper Peptide GHK.Cu GHK-Cu;Ahk-cu;Liver Cell Growth Factor(GHK);GHKcu/Growth-Modulating peptide;(Gly-His-Lys)2Cu.xHAc;Copper Peptide |
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49557-75-7 Biological Activity |
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Description |
Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance[1][2][3]. |
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Related Catalog |
Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease |
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In Vitro |
Glycyl-L-histidyl-L-lysine and its copper complexes and saccharomyces/copper ferment on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line[1]. Glycyl-L-histidyl-L-lysine and its copper complexes decreases TNF-α-dependent IL-6 secretion in fibroblasts[1]. |
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In Vivo |
Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 1.5, 5, 50, 150, and 450 mg/kg; 10 times ) can stimulate mitotic activity of hepatocytes and dose-dependently suppresse immune reactivity[2]. Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 0.5, 5, and 50 μg/kg) can produce an anxiolytic effect in the elevated plus maze test[3]. |
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References |
[1]. Arkadiusz Gruchlik, et al. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2012 Nov-Dec;69(6):1303-6. [2]. M Yu Smakhtin, et al. Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor. Bull Exp Biol Med. 2002 Jun;133(6):586-7. [3]. I Bobyntsev, et al. Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med. 2015 Apr;158(6):726-8. |
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49557-75-7 Chemical & Physical Properties |
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Melting point |
>144°C (dec.) |
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Boiling point |
831.0±65.0 °C at 760 mmHg |
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Density |
1.3±0.1 g/cm3 |
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Molecular Formula |
C14H24N6O4 |
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Molecular Weight |
340.378 |
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Flash Point |
456.4±34.3 °C |
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PSA |
176.22000 |
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LogP |
-2.24 |
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Exact Mass |
340.185913 |
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Vapour Pressure |
0.0±3.2 mmHg at 25°C |
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Index of Refraction |
1.583 |
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storage temp. |
under inert gas (nitrogen or Argon) at 2–8 °C |
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solubility |
Aqueous Acid (Slightly), DMSO (Slightly) |
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49557-75-7 Description |
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Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine. |
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49557-75-7 Uses |
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