2-Phenylacetamide
- CasNo：103-81-1
- Molecular Formula：C<sub>8</sub>H<sub>9</sub>NO
- Purity：
- Molecular Weight：135.166
Product Details
Factory Sells Best Quality 2-Phenylacetamide 103-81-1 with USP
- Molecular Formula:C8H9NO
- Molecular Weight:135.166
- Appearance/Colour:White krystalline powder.
- Vapor Pressure:0.000537mmHg at 25°C
- Melting Point:156 °C
- Refractive Index:1.552
- Boiling Point:312.2 °C at 760 mmHg
- PKA:16.21±0.40(Predicted)
- Flash Point:142.6 °C
- PSA：43.09000
- Density:1.098 g/cm3
- LogP:1.41470
2-Phenylacetamide(Cas 103-81-1) Usage
|
Preparation |
Synthesis of 2-phenylacetamide: Add concentrated hydrochloric acid to phenylacetonitrile, stir to dissolve, and react at 50°C for half an hour. Then slowly add water under cooling to separate out crystals, filter after cooling, wash with ice water to obtain crude product. The crude product was washed with sodium carbonate solution, then washed with ice water, and dried to obtain purer phenylacetamide. |
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Synthesis Reference(s) |
Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005Organic Syntheses, Coll. Vol. 4, p. 760, 1963 |
|
Biological Activity |
2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells. |
|
Safety Profile |
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. |
|
Purification Methods |
Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.] |
|
Definition |
ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid. |
InChI:InChI=1/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)
103-81-1 Relevant articles
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Paragraph 0090-0100, (2021/02/06)
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103-81-1 Process route
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1,3-diphenyl-acetone-(O-benzenesulfonyl oxime )
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7664-41-7
ammonia
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1788-31-4
1,3-diphenylpropan-2-one oxime
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103-81-1
Benzeneacetamide
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5504-24-5
2-phenylacetamidine
| Conditions | Yield |
|---|---|
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Produkt 5: N-Benzyl-phenacetamidin; Produkt 6:Benzylcyanid;
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949146-91-2
(2R)-2-(benzylamino)-2-phenylacetamide
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103-81-1
Benzeneacetamide
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100-46-9
benzylamine
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
In
diethyl ether;
Product distribution;
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103-81-1 Upstream products
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186581-53-3
diazomethane
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98-88-4
benzoyl chloride
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100-42-5
styrene
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103-82-2
phenylacetic acid
103-81-1 Downstream products
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6319-63-7
phenyl-acetic acid xanthen-9-ylamide
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109939-51-7
N,N'-bis-phenylacetyl-furfurylidenediamine
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95275-76-6
5-benzyl-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
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22442-73-5
N,N'-((4-nitrophenyl)methylene)bis(2-phenylacetamide)
