Product Details
Buy Good Quality Plazomicin 1154757-24-0 with a minimum purity of 99%
- Molecular Formula:C25H48N6O10
- Molecular Weight:592.69
- Boiling Point:896.4±65.0 °C(Predicted)
- PKA:13.11±0.20(Predicted)
- PSA：272.78000
- Density:1.40±0.1 g/cm3(Predicted)
- LogP:-1.63810
1154757-24-0 Relevant articles
Synthetic method of plazomicin
-
Paragraph 0015; 0056-0058, (2020/03/25)
The invention discloses a synthetic meth...
Preparation method of plazomicin
-
Paragraph 0015; 0032; 0051-0052, (2020/03/29)
The invention discloses a preparation me...
Preparation method of Plazomicin
-
Paragraph 0021; 0037-0065, (2020/05/30)
The invention provides a preparation met...
Preparation method of pradimicin antibiotics
-
Paragraph 0121; 0125; 0144, (2019/01/08)
The invention provides a preparation met...
1154757-24-0 Process route
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![6'-tert-butyldimethylsiloxyethyl-2',3,3-tri-(tert-butoxycarbonyl)-1-[N-tert-butoxycarbonyl-4-amino-2(S )-hydroxybutyryl]sisomicin](/upload/2025/5/3663abc9-90c0-46de-bbd7-41022d3048f7.png)
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1154758-74-3
6'-tert-butyldimethylsiloxyethyl-2',3,3-tri-(tert-butoxycarbonyl)-1-[N-tert-butoxycarbonyl-4-amino-2(S )-hydroxybutyryl]sisomicin
-
-
1154757-24-0
ACHN-490
| Conditions | Yield |
|---|---|
|
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 35 ℃;
for 2h;
|
60% |
|
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 1h;
|
35.2% |
|
6'-tert-butyldimethylsiloxyethyl-2',3,3"-tri-(tert-butoxycarbonyl)-1-[N-tert-butoxycarbonyl-4-amino-2(S )-hydroxybutyryl]sisomicin;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 0.75h;
With
ammonia; water;
|
|
|
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 0.75h;
|
|
|
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 35 ℃;
for 2h;
|
5.3 g |
-
-
plazomicin phosphate
-
-
1154757-24-0
ACHN-490
| Conditions | Yield |
|---|---|
|
With
anion exchange resin;
In
methanol;
for 10h;
Inert atmosphere;
Green chemistry;
|
1154757-24-0 Upstream products
-
1154758-74-3
6'-tert-butyldimethylsiloxyethyl-2',3,3-tri-(tert-butoxycarbonyl)-1-[N-tert-butoxycarbonyl-4-amino-2(S )-hydroxybutyryl]sisomicin
-
1154758-63-0
tert-butyl ((2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-3-(((2S,3R)-6-(aminomethyl)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-2-yl)oxy)-4-((tert-butoxycarbonyl)amino)-6-((S)-4-((tert-butoxycarbonyl)amino)-2-hydroxybutanamido)-2-hydroxycyclohexyl)oxy)-3,5-dihydroxy-5-methyltetrahydro-2H-pyran-4-yl)(methyl)carbamate
-
32385-11-8
sisomicin
-
1154758-54-9
4-nitrobenzyl (((2S,3R)-3-amino-2-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3,4-dihydro-2H-pyran-6-yl)methyl)carbamate
