Product Details
Reliable factory customized supply MK677 159634-87-4
- Molecular Formula:C32H44N4O7S
- Molecular Weight:628.79
159634-87-4 Relevant articles
Domino Aryne Annulation via a Nucleophilic-Ene Process
Xu, Hai,He, Jia,Shi, Jiarong,Tan, Liang,Qiu, Dachuan,Luo, Xiaohua,Li, Yang
, p. 3555 - 3559 (2018/03/21)
1,2-Benzdiyne equivalents possess the un...
A facile synthesis of the spiroindoline-based growth hormone secretagogue, MK-677
Qi, Xian Liang,Yang, Er Qun,Zhang, Jun Tao,Wang, Tao,Cao, Xiao Ping
, p. 661 - 664 (2012/07/03)
A facile and improved route for the synt...
Wet granulation formulation of a growth hormone secretagogue
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, (2008/06/13)
The present invention relates to a pharm...
Synthesis of the orally active spiroindoline-based Growth Hormone Secretagogue, MK-677
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, p. 10983 - 10992 (2007/10/03)
The preparation of the Merck Growth Horm...
159634-87-4 Process route
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498-94-2
isonipecotic acid
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![N-[(R)-[(1,2-Dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-[(1,1-dimethyl-ethoxy)carbonyl]amino-2-methyl-propanamide](/upload/2025/5/2fa072b7-3a47-480f-ae88-6fa7e343e8ff.png)
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159634-87-4
N-[(R)-[(1,2-Dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-[(1,1-dimethyl-ethoxy)carbonyl]amino-2-methyl-propanamide
| Conditions | Yield |
|---|---|
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Multi-step reaction with 10 steps
1: 97 percent / K2CO3 / H2O / 58 h / 22 °C
2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C
3: 94 percent / H2, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr
4: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C
5: NaBH4 / toluene / 0.5 h / -2 °C
6: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C
7: 93 percent / H2 / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr
8: DCC, HOBt / H2O; various solvent(s) / 5 h / Ambient temperature
9: MsOH / ethanol / 7.5 h / 35 - 40 °C
10: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature
With
sodium tetrahydroborate; oxalyl dichloride; methanesulfonic acid; methyl-phenyl-thioether; hydrogen; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
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Multi-step reaction with 9 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2: potassium carbonate / 20 °C
3: pyridinium chlorochromate / dichloromethane / 20 °C
4: trifluoroacetic acid / dichloromethane
5: sodium tetrahydroborate / methanol
6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran
7: palladium 10% on activated carbon; hydrogen / ethanol
8: benzotriazol-1-ol; dicyclohexyl-carbodiimide / Isopropyl acetate; water
9: benzotriazol-1-ol; dicyclohexyl-carbodiimide / Isopropyl acetate; water
With
sodium tetrahydroborate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; Isopropyl acetate; water;
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138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde
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159634-87-4
N-[(R)-[(1,2-Dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-[(1,1-dimethyl-ethoxy)carbonyl]amino-2-methyl-propanamide
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 7 steps
1: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C
2: NaBH4 / toluene / 0.5 h / -2 °C
3: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C
4: 93 percent / H2 / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr
5: DCC, HOBt / H2O; various solvent(s) / 5 h / Ambient temperature
6: MsOH / ethanol / 7.5 h / 35 - 40 °C
7: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature
With
sodium tetrahydroborate; methanesulfonic acid; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene;
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Multi-step reaction with 6 steps
1: trifluoroacetic acid / dichloromethane
2: sodium tetrahydroborate / methanol
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran
4: palladium 10% on activated carbon; hydrogen / ethanol
5: benzotriazol-1-ol; dicyclohexyl-carbodiimide / Isopropyl acetate; water
6: benzotriazol-1-ol; dicyclohexyl-carbodiimide / Isopropyl acetate; water
With
sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; Isopropyl acetate; water;
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