2,5-Dimethoxyacetophenone

  • CasNo:1201-38-3
  • Molecular Formula:C<sub>10</sub>H<sub>12</sub>O<sub>3</sub>
  • Purity:
  • Molecular Weight:180.203
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Product Details

Fast Delivery 2,5-Dimethoxyacetophenone 1201-38-3 Good Supplier

  • Molecular Formula:C10H12O3
  • Molecular Weight:180.203
  • Appearance/Colour:clear yellow to green-yellow liquid 
  • Melting Point:18-20 ºC 
  • Refractive Index:n20/D 1.5441(lit.)  
  • Boiling Point:294.3 °C at 760 mmHg 
  • Flash Point:111.3 °C 
  • PSA:35.53000 
  • Density:1.139 g/cm3 
  • LogP:1.90640 

2',5'-Dimethoxyacetophenone(Cas 1201-38-3) Usage

Chemical Properties

clear yellow to green-yellow liquid

Uses

2'',5''-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents.

Preparation

Obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide.

Consumer Uses

ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

1201-38-3 Relevant articles

Solid supported Ru(0) nanoparticles: An efficient ligand-free heterogeneous catalyst for aerobic oxidation of benzylic and allylic alcohol to carbonyl

Das, Pralay,Aggarwal, Nidhi,Guha, Nitul Ranjan

, p. 2924 - 2928 (2013)

Polymer immobilized stable, spherical ru...

Design, synthesis and docking study of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors

Abdelaziz, Marwa E.,El-Miligy, Mostafa M.M.,Fahmy, Salwa M.,Mahran, Mona A.,Hazzaa, Aly A.

, p. 674 - 692 (2018)

A series of pyridine and thieno[2,3-b]py...

Solid-supported Pd(0): An efficient heterogeneous catalyst for aerobic oxidation of benzyl alcohols into aldehydes and ketones

Bandna,Aggarwal, Nidhi,Das, Pralay

, p. 4954 - 4956 (2011)

Solid-supported nano- and microparticles...

Phytochemistry of Genus Gentiana. XXVI. Identification of a New Di-O-glucosyl Cinnamoyl-C-glucosylflavone in the Leaves of Gentiana X marcailhouana RY.

Luong, Minh Duc,Saeby, Jan,Fombasso, Pierre,Jacot-Guillarmod, Andre

, p. 2741 - 2745 (1981)

A new di-O-glucosyl cinnamoyl-C-glucosyl...

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Dhami,K.S.,Stothers,J.B.

, p. 479 (1965)

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Preparation method of 2, 5-dimethoxyphenylacetic acid

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Paragraph 0063-0066, (2021/01/29)

The invention belongs to the technical f...

Preparation method of 2,5-dimethoxyphenylacetic acid

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Paragraph 0071; 0072, (2021/02/06)

The invention belongs to the technical f...

Preparation method of 2,5-dimethoxyphenylacetic acid

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Paragraph 0096-0097, (2021/02/06)

The invention belongs to the technical f...

Imidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones

Nguyen, Hai Truong,Ngo, Dung Kim Thi,Chau, Khiem Duy Nguyen,Tran, Phuong Hoang

, p. 157 - 165 (2021/03/16)

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1201-38-3 Process route

acetic acid
64-19-7,77671-22-8

acetic acid

1,4-dimethoxybezene
150-78-7

1,4-dimethoxybezene

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one
705-15-7

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

2',5'-dimethoxyacetophenone
1201-38-3

2',5'-dimethoxyacetophenone

Conditions
Conditions Yield
With boron trifluoride;
aluminium trichloride
7446-70-0

aluminium trichloride

diethyl ether
60-29-7,927820-24-4

diethyl ether

acetyl chloride
75-36-5

acetyl chloride

1,4-dimethoxybezene
150-78-7

1,4-dimethoxybezene

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one
705-15-7

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

2',5'-dimethoxyacetophenone
1201-38-3

2',5'-dimethoxyacetophenone

Conditions
Conditions Yield

1201-38-3 Upstream products

  • 108-24-7
    108-24-7

    acetic anhydride

  • 150-78-7
    150-78-7

    1,4-dimethoxybezene

  • 64-19-7
    64-19-7

    acetic acid

  • 75-36-5
    75-36-5

    acetyl chloride

1201-38-3 Downstream products

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    145091-58-3

    2-(1-ethyl-vinyl)-1,4-dimethoxy-benzene

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    (E)-1-(2,5-dimethoxyphenyl)-3-(3,4-methylenedioxyphenyl)-prop-2- en-1-one

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    6665-83-4

    6-hydroxyflavone